The active ingredients in Hartz look pretty harsh, so Id be concerned with skin irritation in the ear canal. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. Im sincerely grateful!! But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. Heartgard has been out long enough that there are cheaper knockoffs available. , I use Advecta 3 because it prevents and kills I have been in the dog Bussiness for over 26 years and used to use frontline bit past few years switched because frontline doesnt prevent .I never had a problem with advecta 3 and hope its safe, As this is a Collie blog and I assume the majority of people who read this post have a Collie, Im just hesitant to recommend it since many Collies have issues with sensitive skin even if theyre clear of MDR1. It just depends on the individual dog. The Whole Dog Journal notes that Ivermectin has the most potential for toxicity.. Is Simparica Safe for Dogs? Scroll down to read their comments. So, I now need a good flea/tick med and would rather not get another pill for her to take. The manufacturer of Heartgard has tested the product for safety in dogs with the MDR1 mutation. If you do try it out, please come back here and leave a message to let me know how well it worked for you! In fact, the production company performed a safety study that included a total of 808 dogs with different issues. Later, the vet had the experience of this happening to other cats and one of his own. Happy to help! Bear in mind a dog can negatively react to anything though, so its always best practice to keep a close eye on them after administering any new product! At high doses, however, such as those used in treating parasites such as demodectic mange, ivermectin can cause neurologic effects in dogs with the MDR1 mutation. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? If you have one of those rare dogs who is just going to react to every heartworm medication (fingers and toes crossed thats not the case), then you might want to consider frequent heartworm tests as an alternative to regular heartworm treatment. Dr. Judy Morgan described the case of a Beagle brought to her that was suffering from seizures, which were likely the result of or worsened by being wrongly prescribed Nexgard in combination with another medication. Any of the -mectins are only safe for MDR1-prone breeds at the recommended dosage. A combination of -mectin in topical and oral form could definitely cause negative reactions if any of your foster puppies have MDR1. Thanks for your informative article. for, I think its brown ticks. Unless youre, say, an expat living in China, you can definitely find a better option. What an awesome article. Personally, I would be concerned about missing a daily dose. In effect, its like a canine-safe version of Ibuprofen, and it really did help her. Honestly, I think K9 Advantix would beat Credelio as far as effectiveness, due to its repellent properties and ability to kill on contact. Your article was appreciated and helpful! What are your thoughts on that? I dont believe Advocate is marketed here in the US, but in Australia it looks to be Elancos version of Advantage Multi, marketed by Bayer. If the tablet is not taken up voluntarily by the dog it can also be given with food or directly into . . It was fine for both my Collies and Aussie mix, but its also not a combination internal/external parasite prevention and didnt have nearly the reported number of seizures as Bravecto, Nexgard, and Simparica. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. I went back and edited my comment for consistency. The FDA determined Revolution is safe for dogs with the MDR1 mutation when used at label doses. Positive feedback keeps me writing! I will not give anything oral to my dog, since our first collie was probably killed by heartworm preventative. If you have a dog you suspect has Giardia, it really is best to see a veterinarian. Safe in breeding, pregnant and lactating dogs. Somewhere I read that its good for 4 kinds. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Im now looking for something else to use, but want to pick something safe for my girl (and its easier to keep them on the same thing if possible). Thank you! My personal vet is knowledgeable of the MDR1 gene mutation (now also referred to as the ABCB1 mutation), and he recommended Interceptor to me for my mutant/normal Collies. It has the same active ingredients as Seresto (plus one), so a bit stronger. We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. Which Breeds Are Affected? Eating poison. Simparica Trio chewable tablets for dogs 1.25-2.5 kg Simparica Trio chewable tablets for dogs >2.5-5 kg . Personally I use Frontline Plus and supplement weekly with a Natural Chemistry spray as a repellent, but I understand that might not be ideal for everyone depending on their situations. Safe for dogs from 1.25 kg; Can be given with our without food; Pork liver flavoured chewable tablet; Safe in heartworm positive dogs; Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Heartworm. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! ? The bottom line is, its best to avoid giving your Collie Heartgard or a similar medication. Though water resistant, frequent bathing or swimming (once a month or more) will reduce the collars effective time to 5 months or less. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. I have a new Collie-mix with bi-coloured coat. Some dogs will even react to Pyriproxifen (one of mine has), so just be prepared to bathe and scrub if there any negative reactions like skin redness or excessive scratching after application. . Im leaning toward Frontline Plus based on what you wrote. You can also reach me through the contact form here on the website. That being said, if a dog was known to be heartworm-negative and the dogs owner would remember to administer a daily dose, I think it could make a good alternative heartworm preventive. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). Bottom line is that Simparica will probably be fine for your dog, but there is a slight risk that it wont. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. Comes as: a vial of liquid applied to the back of the neck on a monthly basis (fipronil) Used for tick control every two weeks if travelling to the eastern states. A1443) is a novel systemic ectoparasiticide and belongs to the class of isoxazolines, also including afoxolaner, lotilaner and sarolaner [ 1, 2 ]. MDR1 is the abbreviated name of a gene called Multi-Drug Resistance 1. Under many circumstances, newer dog flea collars are safe options for flea and tick control (unlike older collars, which were largely ineffective). The FDA determined ProHeart is safe for dogs with the MDR1 mutation when used at label doses. I have never even heard of the latter and do not believe they exist in Canada. (1) Use a natural brewer's yeast + garlic supplement (2) Use a natural flea & tick spray on your pet daily during warm months (3) Treat your yard using a natural product such as diatomaceous earth or Wondercide (4) Check your australian shepherd daily (during warmer months) for fleas and ticks. Thats a good point about the potentially smaller user sample size for Credelio, since its a newer medication that hasnt been out as long as the others. This gave me a great start for research. Fluralaner (syn. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. Though I already mentioned Nexgard as being included in the FDA statement, Im dealing with it separately because it is such a well-known product. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. I went back to using Frontline Plus for them. (One such knockoff, Pet Armor Plus, is even available at Walmart.). The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Its simpler to identify medicines by their components, since many of them are essentially the same thing marketed under different brand names. My pleasure! Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. That was only 1 out of 4 dogs, but I just feel better in general sticking to topicals. Here are a few of the safest flea treatments for dogs on the market today and some of their pros and cons. (There are 13 other at-risk breeds including Border Collies, Australian Shepherds, German Shepherds, Shetland Sheepdogs, and Old English Sheepdogs, plus herding breed mixes.) Thank you for this thorough and thoughtful work, Emily! Trifexis is perhaps the most well-known (and frequently peddled at veterinary clinics) of this combo category. Remember she is fixed. Hope this helps! The vet thought he would be nice and put Advantage Multi on our cats. Unfortunately, the fleas are fighting back. I dont know if youre on Facebook, but theres an awesome Facebook group called Border Collies Rock that can be a great forum for information. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. Turns out it is also used for the treatment and prevention of roundworms and lungworm nemotodes in dogs, according to Vet Shop Max. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. Thanks for reply. Simparica is for use only in dogs 6 months of age and older. On the downside, its efficacy only lasts for about a day. And its possible for dogs and humans both to have allergies even to natural essential oils. The FDA approved Nexgard for flea treatment in dogs in September 2013, Bravecto in May 2014, Simparica in February 2016, and Credelio in January 2018. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. Liver disease. At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. . Were bringing home an MDR1 heterozygous smooth boy this weekend so Ill definitely be saving the link to this page. Also what can be used for giardia? Dogs with the MDR1 mutation are at risk of serious drug toxicities at doses that are safe to other dogs. Leaders in MDR1 testing since 2004. Multi-Drug Resistance 1 (MDR1) is a gene that is meant for helping to protect the brain. Emma. . But of course, do talk to your vet and see what they know. Your sense of humor is enlightening also. You probably already know Frontline Gold can be toxic to cats, since it has a caution on the label, but this is only really a concern if you have a cat who cuddles with or grooms your dogs. It can be used to destroy bedbugs, cockroaches, ants, and even fleas. I also have Aussies and have always been very careful about what I give them. Our dogs deserve the best. The active ingredients of SimpleGuard 3 are the same as Vectra 3D: dinotefuran, pyriproxifen, and permethrin. new post updates in monthly email newsletters. Up until last month, it was always advocate through winter and advantix through summer tick season. safe for dogs Approved for puppies as young as 8 weeks old weighing 2.8 lbs or more Highly palatable 1 liver-flavored chewable Can be given with or without food. Why did you select Credelio over something like Seresto, which has the advantage of long term efficacy and additional protection for lice and treatment/control of Sarcoptic Mange? The manufacturer of ProHeart has tested the product for safety in dogs with the MDR1 mutation. That indicates it is a strong chemical compound, so do watch for skin irritation. Id like to have a Smooth Collie in the future. Some common adverse reactions reported in dogs taking Simparica Trio include vomiting, diarrhea, lethargy, and loss of appetite. THREE OF THE 8 FEMALES WENT INTO ESTRUS. Great summary! Where can I get them tested for MDR1 resistance. Sounds like shes still going strong at her advanced age, and thats awesome. However, its technically safe so long as it isnt applied past the shoulder blades where your Collie could reach it. Dog Flea and Tick Collars. I need to pivot, and looking at Frontline there are two new Frontline products to combat the flea resistance. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Id like to have a Border Collie one day, but as I have some health issues Im not sure I could keep up with one. 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